The Water for the Food Baskets of the World Grand Challenge focuses on three main regions of the globe. In North America, the Grand Challenge is represented by the Changing Cold Regions Network (CCRN), which covers the Saskatchewan and Mackenzie River basins in Canada. CCRN is a large, active research project, also a recognized GEWEX Regional Hydroclimate Project (RHP). To extend the area of study in North America, a new U.S.-based RHP is also under consideration.

In Europe, PannEx, the developing RHP in the Pannonian basin, is just getting off the ground. This region is traditionally not well-studied, and presents an opportunity to take a look at interesting hydrological and atmospheric boundary layer processes.

In Asia, the area of interest is the high, mountainous regions of Central Asia. This location, influenced by monsoon processes, produces wheat and rice.